Abstract
Multiple cranial nerve palsies are clinical conundrums that can be solved by determining zones of the proximity of the affected nerves. The affliction of two or more contiguous neuroanatomic structures helps in the localization of the causative lesion. However, there are certain caveats to this method of estimation when it may not be applicable such as in cases of multifocal or diffuse pathologies and large mass lesions. Orbital apex disorders refer to the clinical spectrum arising from lesions in the orbital apex, superior orbital fissure, and cavernous sinus. Besides, large neoplasms in the middle cranial fossa too may have a similar presentation. It is essential to consider the possibility of false localizing signs, as is highlighted in our two case reports, both of which initially appeared to be caused by orbital apex region lesions.
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