Psödoeksfoliasyon Sendromunda Kuru Göz ve Meibomian Bez Disfonksiyonunun Meibografi ile Değerlendirilmesi

Abstract

Objectives: To evaluate morphological changes caused by pseudoexfoliation (PEX) syndrome in meibomian glands with meibography. Material and Methods: 39 individuals with PEX syndrome and 42 individuals without PEX syndrome were included in the study. Meibomian glands, tear-film break-up time, tear volume and subjective symptoms of the study and control groups were evaluated with followings, respectively: meibography, non-invasive keratographic tear film break-up time (NIKBUT), Schirmer 1 test with anesthesia, ocular surface disease index (OSDI) questionnaire. Results: Schirmer 1 and NIKBUT values were found to be significantly lower in the participants with PEX syndrome compared to the control group (p<0.001, p=0.012; respectively). But the OSDI index and total meibograde values were found to be significantly higher in the PEX syndrome group compared to the control group (p=0.002, p<0.001; respectively). Additionally, in the PEX syndrome group, a negative correlation was determined between total meibograde value and NIKBUT value (r:-0.673; p=0.001) and a positive correlation was determined between total meibograde value and OSDI index score value (r: 0.515; p<0.001). No statistically significant correlation was determined between total meibograde value and Schirmer 1 value (p=0.847). Conclusion: PEX syndrome affects the ocular surface adversely. Causing the meibomian gland dropout by this syndrome is also among the mechanisms of this adverse effect. This condition should be considered for the diagnosis and treatment approach of dry eye disease in patients with PEX syndrome.