PS-C35-3: EFFECT OF BMI REDUCTION ON BLOOD PRESSURE CHANGES IN OVERWEIGHT PATIENT: A SYSTEMATIC REVIEW AND META-ANALYSIS

Abstract

Objective: To determine quantitative differences between weight loss and changes in clinic blood pressure (BP) in overweight patient, a systematic review and meta-analysis of randomised trials was performed. Design and method: A systematic literature search was conducted to identify relevant studies in the PubMed, Embase and Scopus databases up to April 2022. Only studies with English language were included. Studies were considered for inclusion if they met the following criteria: (1) included comparison clinical BP between weight loss; (2) the mean values and standard deviations (SD) of clinical BP and BMI were reported respectively; (3)all patients have a BMI ≧ 25 kg/m2. The certainty of evidence was used the GRADE approach. All statistical analyses were performed using Revman 5. Results: Twenty-four studies, for a total of 2614 patients were included in this meta-analysis. The clinic systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly reduced by 7.04 mmHg (95% CI, 5.04–9.03) and 4.40 mmHg (95% CI, 3.17–5.62) after a mean body mass index (BMI) reduction of 2.42 Kg/m2. The BP reductions were much larger in patients with a BMI decrease ≧ 3 kg/m2 than in patient with less BMI decrease, both for SBP [10.32 mmHg (95% CI, 6.15–14.49)] vs. [5.79 mmHg (95% CI, 3.19–8.39)] and DBP [7.48 mmHg (95% CI, 4.50–10.47)] vs [3.93 mmHg (95% CI, 2.15–5.70)]. The BP reductions were also much larger in patients with a baseline BMI ≧ 30 kg/m2 than in patients with a lower BMI, both for SBP [8.90 mmHg (95% CI, 5.97–11.83) vs. 5.25 mmHg (95% CI, 2.19–8.31)] and DBP [6.02 mmHg (95% CI, 3.89–8.14) vs. 3.82 mmHg (95% CI, 1.78–5.86)]. Furthermore, the SBP and DBP reductions in patients with medical interventions (ie drugs and surgeries) were 9.22 mmHg (95% CI, 6.36–12.08) and 6.11 mmHg (95% CI, 3.29–8.92) respectively, which were larger than patients with lifestyle interventions both for SBP [4.69 mmHg (95% CI, 2.81–6.57)] and DBP [3.82 mmHg (95% CI, 2.22–5.43)]. Conclusions: The significant reduction of clinic BP followed the weight loss, and this phenomenon could be more notable after medical intervention and a larger weight loss.