PS-C14-10: THE INFLUENCE OF ARTERIAL HYPERTENSION ON THE PROGRESSION OF OBSTRUCTION IN HYPERTROPHIC CARDIOMYOPATHY

Abstract

The nature of hypertrophic cardiomyopathy remains unexplored to date, but there is a very reasonable opinion about the genetic transmission of the disease. Given the presence of arterial hypertension in 88% of patients with hypertrophic cardiomyopathy, the issue remains relevant. To date, there is no clear understanding of hypertrophy in hypertrophic cardiomyopathy and hypertensive heart. Objective: To evaluate the effect of arterial hypertension on obstruction in hypertrophic cardiomyopathy. Material and Methods: From 2017 to 2022, 70 patients diagnosed with hypertrophic cardiomyopathy were under observation. Given the obstructive form of hypertrophic cardiomyopathy, 40 patients were operated on, Morrow operation, 30 patients diagnosed with hypertrophic cardiomyopathy without obstructive lesions are under observation, this group will take part in the study. All patients underwent genetic testing. The age of the patients ranged from 18.3 to 80.4 years, the median was 57.3 years; in most cases, pathology occurs in females, 67%, while in men it is 2 times less, 33%. Exclusion criteria for patients with aortic stenosis and “athletic” heart. Complaints were shortness of breath, headaches, dizziness, syncope. Results as a result of studies in 56% of patients test for genetic mutations is positive. Arterial hypertension was detected in 88% of patients. The duration of the disease in patients varied significantly from 1 to 35 years, the interquartile range was from 5.3 to 15.1 years, the median was 10 years. Systolic blood pressure in patients ranged from 92 to 260 mm Hg, the median was 180.5 mm Hg. Diastolic blood pressure in patients ranged from 61 to 130 mm Hg, the median was 90 mm Hg. In patients with a negative genetic analysis, 44%, a long history of arterial hypertension was revealed. Most of the patients were not adherent to therapy, despite the 3rd degree of arterial hypertension, only 13% were constantly taking antihypertensive drugs. Considering these data, we identified relevant data on echocardiography. In patients with a long history of hypertension, an increase in the left atrium, a concentric variant of hypertrophy, can be noted. There is thickening of both the aorta and the aortic valve cusps. Conclusions: The mechanism of development of hypertrophic cardiomyopathy is not completely clear; therefore, the genetic diagnosis of this disease is an integral part. Timely identified and initiated treatment of hypertension can prevent the risks of developing hypertrophy in the future.