Abstract
Background Early infant CRP levels in the setting of Chorioamnionitis (CA) have not been fully defined as a predictor of cognitive, behavioural, and neuro-developmental outcomes among extremely preterm neonates. Methods 499 preterm neonates had Placental pathology, CRP level and Vermont Oxford outcomes recorded. Death and developmental outcomes at 2 yrs were examined for 247 preterm infants Results 499 preterm infants were included with mean birth weight of 1074 +/- 273 g and gestational age of 28.5 +/-2.7 weeks. Infants with CA (N = 127) had lower GA and birth weight and higher rates of early onset sepsis. The Fetal inflammatory response was associated with: Apgar Infants with Day 1 CRP >10 mg/L needed significantly more resuscitation in the Delivery room (DR) including adrenaline and cardiac compressions. They were significantly more at risk of RDS, ROP, grade III/IV IVH. Conclusion There is a correlation between both initial CRP and histological CA with adverse short term outcomes.
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