Abstract
MIDD (Maternally Inherited Diabetes and Deafness) and MELAS (Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like episodes) are related syndromes both associated with the m.3243A>G mutation. A patient with this mutation, previously diagnosed with MIDD, is described who showed two remarkable clinical features: severe insulin resistance and the development of MELAS over time.
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