PS2 - 7. A 5-day high fat high calorie diet impairs insulin sensitivity in healthy, young, lean male Hindostani but not in Caucasians

Abstract

People of South-Asian descent, such as the Surinamese Indo-Asian (Hindostani) population in The Netherlands, develop type 2 diabetes and cardiovascular disease at a much younger age and BMI as compared to the Caucasian population. Moreover, the incidence and seriousness of these diseases is much higher in Hindostani as compared to Caucasians. The cause of these differences is unknown but might be (among others) causally related to body fat distribution and/or fatty acid handling. This study investigates whether there are differences in insulin sensitivity between healthy, young, lean male Hindostani and Caucasians at baseline, and whether the response in insulin sensitivity to a 5-day high fat high calorie (HFHC) diet differs between both ethnicities.