Abstract
Ketogenic diets (KD) are effective for weight loss and for treatment of refractory epilepsy. Patients on a high-fat and low-carbohydrate diet switch from a carbohydrate-based to a fat-based energy metabolism, which leads to a permanent state of ketosis. Recently, short-time studies in rodents have shown that besides their beneficial effect on body weight, KD lead to glucose intolerance and hepatic insulin resistance.
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