Abstract
Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme of triglyceride hydrolysis and is mainly expressed in adipocytes and myocytes, thus ATGL-KO mice show abnormal triglyceride accumulation in those tissues. Intramyocellular lipids (IMCL) are often used as biomarker of insulin resistance and type 2 diabetes, potentially reflecting lipotoxic effects on mitochondrial function. Whether IMCL accumulation per se has adverse effects on mitochondria is unclear. Therefore, we assessed IMCL levels and mitochondrial oxidative capacity of ATGL-KO mice in vivo with 1HMRS and gated-dynamic-31PMRS of contracting calf-muscles.
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