Abstract
Background:Shortage of replacement therapy in haemophilia is responsible for the devastating consequences of uncontrolled bleeds, with unfavourable impact on the quality of life, strongly dependent on oro‐dental health.Aims:The objective of our study was to analyse the dental status in persons with haemophilia (PwH) in our treatment conditions, characterised by the introduction of on demand replacement in 1997 and of prophylaxis in 2014‐2015.Methods:This descriptive non‐interventional cross‐sectional study was conducted on 47 PwH (12 children, 35 adults), all with severe form of disease and on a control matched group of 47 persons. For each PwH were recorded laboratory data and history of replacement therapy. Oral health status evaluation was performed according to the criteria suggested by World Health Organization (WHO).Results:We assessed a very bad dental status in PwH with very high values for the majority of the parameters. In haemophilic children comparable to matched control group there were significant differences regarding the D index and PL index (p = 0.04, p = 0.01). Concerning the domain of decayed teeth in children we observed the existence of an age correlation (r = 0.47/0.81), unfortunately with a lowering appeal for dental care in children with haemophilia, the F index (0.2 ± 0.4) being decreased compared to the children from control group (2.2 ± 2.2), with significant difference (p = 0.003). The dental indexes in adult haemophiliacs were found high, significantly higher in the field of D and F than those belonging to the control group. F index was found significantly higher in the control group than in PwH, proving the low addressability for dental care in haemophiliacs. All these results, with the exception of Missing teeth and DMFT index (r = 0.63/r = 0.65), were not correlated with the age. Adult PwH, with mean age of 34.8 ± 9.81 years, had a dismal dental profile, only 7/35 had a complete denture, 7/35 missing 25%, and 3/35 missing more than 50% of their teeth.Summary/Conclusion:Lack of access to treatment or a low consumption, especially in young age, can influence and have a decisive impact on oral health status in PwH. Our results highlight the importance of an accessible dental care for this vulnerable group of patients in the frame of a comprehensive haemophilia care, including preventive dental treatment and an adequate replacement therapy.
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