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Abstract
The contribution of calcium Orai channels to contractile responses in human corpus cavernosum and penile arteries has been proposed, especially in pathological conditions such as erectile dysfunction (ED). The aim of the present work was to evaluate the influence of aging on Orai channels contribution to cavernosal tissue contraction. The effect of the Orai channel inhibitor, YM-58483 (YM) was evaluated on contractions induced by norepinephrine (NE) in corpus cavernosum (CC) from young (3 months-old) and aged (20 months-old) rats. The effects of YM on endothelial relaxation and neurogenic contraction were also evaluated in tissues from aged rats. As well, the influence of YM on NE-induced contractions was determined in human corpus cavernosum (HCC) from organ donors (OD) without history of ED, which were divided into younger than 65 years (43.5±2.8 years, n=16) and older than 65 years (74.2±3.5 years, n=5). The expression of Orai channels in these HCCs was determined by Western blot.
Published Version
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