Abstract
Abstract Background Esophageal cancer surgery with lymphadenectomy is known as a cause of weight loss during perioperative period, but the change of body composition is unclear. Methods The aim of study is to clarify the influence of body composition change after esophagectomy. 144 patients(51 cases without NAC and 93 cases with NAC: 98 cases with less than G2 perioperative complications and 46 cases with G2 or more perioperative complications: 36 cases with recurrence and 108 cases without recurrence were included) of esophageal cancer who underwent esophagectomy with lymphadenectomy from August 2011 to December 2016 and evaluated body composition examination before operation and after operation(1, 3, 6 month) were included in this study. We compared the change of body composition between with or without preoperative chemotherapy, postoperative complication, and recurrence. Results The weight loss rate at discharging hospital, 1,3,6 month after discharge for without NAC group/with NAC group was 3.3/3.8%, 7.8/6.8%, 10.1/9.2%, 11.1/9.1% (NS), and the lean body mass reduction rate was 4.1/4.5%, 7.1/6.6%, 6.5/6.7% (N.S.), 6.6/4.3% (P < 0.05). The weight loss rate for with less than G2 perioperative complication group/with G2 or more perioperative complication group was 2.9/4.9%(P < 0.01), 6.1/8.7%(P < 0.01), 8.4/12.1%(P < 0.01), 8.4/11.2%(P < 0.05), and the lean body mass reduction rate was 3.7/5.9%(P < 0.05), 5.9/9.0%(P < 0.01), 5.6/9.6%(P < 0.01), 4.4/5.5%(N.S.). And there was no significant differences of weight loss rate and lean body mass reduction rate at discharging hospital, 1,3,6 month after discharge between with recurrence group and without recurrence group. Conclusion Due to postoperative complications after esophagectomy, the rate of weight loss increased from hospital discharge to 6 months after discharge. Particularly, lean body mass was reduced within 3 months. So, we may have a strategy such as continuing enteral nutrition even after discharge for complicated cases. Disclosure All authors have declared no conflicts of interest.
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