PS01.165: HIGH BMI HAS NO IMPACT ON THE SURVIVAL OF CHINESE PATIENTS WITH ESOPHAGEAL ADENOCARCINOMA TREATED WITH CURATIVE ESOPHAGECTOMY: A PROPENSITY SCORE-MATCHED STUDY

Abstract

Abstract Background Controversy still exists as to whether high BMI has any impact on the long-term survival of esophageal cancer patients treated with curative esophagectomy. Due to the rarity of esophageal adenocarcinoma in Chinese patients, its characteristics were rarely reported and the prognostic value of high BMI in Chinese esopaheagl adenocarcinoma patients has not been investigated yet. Therefore, we conducted this propensity score-matched study to explore the prognostic value of high BMI in Chinese patients with esophageal adenocarcinoma for the first time. Methods We retrospectively collected data of patients with lower thoracic esophageal adenocarcinoma who underwent curative esophagectomy in our department from January 2009 to December 2016. Patients were grouped into high BMI group (≥ 23 kg/m2) and normal BMI group (18.5–22.9 kg/m2) according to the Asian specific BMI cutoff value. Both Cox regression survival analysis and propensity score-matched analysis were applied. Results A total of 132 patients were included for analysis. Fifty-three patients were in the high BMI group while 79 patients were in the normal BMI group. There were no significant differences regarding age, gender, comorbidity, tumor differentiation, tumor site, lymphovascular invasion, or surgical approaches between the two groups. However, patients in the high BMI group had more stage III diseases but less rate of adjuvant therapy than patients in the normal group. For survival, there was no significant survival difference between patients with high BMI and those with normal BMI (5-year overall survival rate: 40.8%VS 48.1%; P = 0.398). In the multivariate analysis, high BMI was not found to be an independent prognostic factor of Chinese patients with esophageal adenocarcinoma (HR = 1.028, 95%CI: 0.621–1.667, P = 0.945). A total of 92 patients were included after propensity-score matched analysis, and all those baseline data were comparable between the two groups. However, there was still no significant difference of survival between patients with high BMI and those with normal BMI (5-year overall survival rate: 41.4%VS 43.3%; P = 0.760). Conclusion High BMI have no impact on survival of Chinese patients with lower thoracic esophageal adenocarcinoma treated with curative esophagectomy. Therefore, esophageal adenocarcinoma patients with high BMI should not be denied for curative esophagectomy. Disclosure All authors have declared no conflicts of interest.