PS01.164: NEUROENDOCRINE CARCINOMA OF THE ESOPHAGUS: AN ANALYSIS OF 72 COHORT PATIENTS SURGICALLY TREATED FROM A SINGLE CHINESE MEDICAL CENTER

Abstract

Abstract Background Esophageal neuroendocrine carcinoma (NEC) is a rare malignant tumor, and it is rarely reported in large cohort studies. Therefore, the prognostic factors of esophageal NEC were not well established. In this study, we tried to analyse a large cohort of esophageal NEC patients aiming to investigate its possible prognostic factors. Methods Patients who underwent esophagectomy for esophageal NEC in our department from January 2007 to June 2015 were identified and analyzed. Both univariate and multivariate analyses were applied to identify potential prognostic factors. Results A total of 72 patients were identified for analysis. After a median follow-up time of 54.8 months, the median survival time of those patients was 21.5 months. One-year, three year, and five-year survival rates were for all those patients were 75.0%, 33.4%, and 28.4% respectively. In the univariate analysis, TNM stage (P = 0.001), lymph node metastasis (P = 0.008), and adjuvant therapy (P = 0.001) were found to significantly influence the overall survival time of those patients; while in multivariate analysis, only TNM stage (P = 0.018) and adjuvant therapy (P = 0.002) were found to be independent prognostic factors. Conclusion Esophageal NEC was extremely rare with poor prognosis. TNM stage and adjuvant therapy are the independent prognostic factors of esophageal NEC. Disclosure All authors have declared no conflicts of interest.