PS01.013: CLINICAL SIGNIFICANCE OF ESOPHAGOGASTRODUODENOSCOPY IN PATIENTS WITH ESOPHAGEAL MOTILITY DISORDERS

Abstract

Abstract Background Although dysphagia is an indication for esophagogastroduodenoscopy (EGD) its causes include organic and non-organic disorders. There has been no study to investigate the clinical significance of EGD in patients with esophageal motility disorders (EMD). The first aim was to elucidate the detection ratio for EMD with EGD. The second aim was to clarify useful EGD parameters associated with them. Methods Participants included 372 patients who underwent EGD before high resolution manometry for dysphagia. EGD findings were investigated according to the following five parameters: resistance when passing through the esophagogastric junction (EGJ), residue in the esophageal lumen, esophageal dilation, spastic and non-occlusive contraction. The EGD finding was positive when at least one EGD finding was detected. HRM diagnoses were made based on the Chicago classification (v3.0). Results Of 372 participants, pseudoachalasia were diagnosed in 6 patients (1.61%), EMD in 250, and normal in 116. The detection ratio for each EMD by EGD is shown in Table 1. There were significant differences in the detection ratio among the three groups (81.1% in major, 50.0% in minor EMD and 15.5% in normal, P < 0.05). On multivariate analysis, resistance when passing through the EGJ (adjusted odds ratio (aOR): 3.99; 95% CI [1.26–12.66]), and non-occlusive contraction (aOR: 10.3; 95% CI [5.26–20.19]) were significantly associated with EMD. Conclusion The ratio of abnormal EGD findings was different in each EMD. Major EMD can be screened with EGD. Among several endoscopic parameters related with EMD, the non-occlusive contraction is most useful endoscopic parameter. Disclosure All authors have declared no conflicts of interest.