Abstract
Abstract Background Chronic inflammatory demyelinating polyneuropathy(CIDP) is a rare problem in liver transplantation recipients. We observed three patients with slowly progressive muscle weakness and dysphagia with body weight loss. Methods We describe the clinical features and high resolution impedance manometry(HRiM) results of 3 patients with liver transplantation who developed CIDP. Two patients had orthotopic liver transplantation and the other had living-donor liver transplantation. Results All 3 patients developed muscle weakness, dysphagia and body weight loss in the period of tapering immune suppressants. Diagnosis of CIDP were checked by neurologist consultation. All patients had immunosuppressive therapy with tacrolimus. Prednisolone in two cases and everolimus in one case were noted. Telbivudine treatment for chronic hepatitis B were given in all 3 patients. After HRiM evaluation, decreased functional oral intake scale(FOIS), distal contractile integral(DCI) and complete bolus rate were discovered. Plasma exchange were done and the follow up HRiM result showed obvious improved FOIS and DCI. Conclusion HRiM is a feasible and effective tool for evaluation of dysphagia in CIDP patients. This exam can be utilized before and after proper treatment. Disclosure All authors have declared no conflicts of interest.
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