PS-P13-2: ASSOCIATION BETWEEN TRIGLYCERIDE-GLUCOSE INDEX AND TARGET ORGAN DAMAGES IN HYPERTENSIVE PATIENTS

Abstract

Objective: To investigate the association between triglyceride-glucose index (TyG index) and albuminuria and left ventricular hypertrophy (LVH) in adults with hypertension. Methods: The study participants were recruited from a residential area in the suburb of Putuo district in Shanghai. We administered a standard questionnaire for basic information and history of diseases. Clinic blood pressure was measured by an experienced physician with the Omron HEM-7124 monitor (Omron HealthCare, Kyoto, Japan). Venous blood samples were drawn after overnight fasting for biochemical measurements, electrocardiogram (ECG)- left ventricular hypertrophy (LVH) was defined according to the Cornell product index and urinary routine test was performed on fresh urine samples. Results: The 5 190 subjects had a mean age of (66.41 ± 7.77) years, and included 2 423 (46.7%) men. Compared with women, men has a little lower TyG index (8.64 ± 0.58 vs 8.69 ± 0.55, P = 0.001). when divided the patients into three groups according to the tertile of TyG index (TyG index less than 8.39, 8.39 - TyG - 8.85, TyG index greater or equal to 8.85), the prevalence of LVH were 4.0%, 3.7% and 6.0%, P for trend = 0.004, and the prevalence of albuminuria were 1.9%, 2.0% and 3.0%, P for trend = 0.03, respectively. After adjustment for related risk factors, the risk for LVH elevated 64% with one unite increase of TyG index, the odds ratio (OR) and 95% confidence interval (CI) was 1.64 (1.31–2.04, P = 0.001). However, there was no significant association between the prevalence of albuminuria and TyG index (OR 0.92, 95% CI 0.56–1.50, P = 0.73). Conclusions: TyG index was associated with LVH and albuminuria, and was an independent risk factor for LVH in hypertension.