PS-P08-9: DEPRESSION IS ASSOCIATED WITH NEW-ONSET DIABETES MELLITUS, BUT NOT HYPERTENSION, IN THE GENERAL POPULATION

Abstract

Objective: Epidemiological studies have shown that depression is a risk factor for cardiovascular disease, however, the mechanism underlying this association is yet unclear especially in the general populations. The aim of this study was to evaluate the relationship between depression and new-onset hypertension/diabetes mellitus in the general population. Design and Method: Individuals from the general population who participated in a medical check-up both in 2019 and 2020 were enrolled in this study. Fasting blood and urinary samples were taken for biochemical analysis, and depression was assessed by using Self-rating Depression Scale (SDS). Hypertension was defined as blood pressure of more than or equal to 140/90 mmHg or use of anti-hypertensive drugs. Diabetes mellitus was defined as fasting blood glucose of more than or equal to 126 mg/dL or HbA1c of 6.5% or use of anti-diabetic drugs. Multivariate logistic regression models were used to calculate odds ratios for new-onset hypertension and diabetes mellitus in 2020 after adjustment for possible confounding factors. Results: Among 550 participants without present hypertension in 2019, 124 developed hypertension in 2020. Similarly, among 890 participants without diabetes mellitus in 2019, 39 developed diabetes in 2020. Multivariate logistic regression analysis showed that severe depression (SDS score of more than or equal to 48) was significantly associated with new-onset diabetes mellitus (odds ratio: 2.558, 95%CI: 1.009–6.487, p = 0.048), but not with new-onset hypertension (odds ratio: 0.943, 95%CI: 0.434–2.051, p = 0.883) after adjustment for potential risk factors. Conclusions: In conclusion, severe depression may be a possible predictor of new-onset diabetes mellitus in the general population.