PS-P05-5: CHANGES IN BLOOD PRESSURE CONTROL, TARGET ORGAN DAMAGE AND CARDIOVASCULAR RISK FACTORS IN HYPERTENSIVE SUBJECTS UNDER ANTIHYPERTENSIVES DURING 9 YEARS

Abstract

Objective: Since an increase in blood pressure is one of the most important risk factors for cardiovascular morbidity and mortality, appropriate blood pressure control is necessary to prevent target organ damages and cardiovascular diseases. We investigated changes in blood pressure control, target organ damage and cardiovascular risk factors of hypertensive subjects under antihypertensive medications from 2010 to 2019. Design and Methods: A total of 1679 and 1884 hypertensive subjects under antihypertensive medications (62.8 ± 9.8 and 65.8 ± 9.4 year-old, respectively) who visited our hospital for physical checkup in 2010 and 1019, respectively, were enrolled. Subjects were divided into two groups; controlled (blood pressure < 140/90mmHg) and not-controlled groups (blood pressure > = 140/90mmHg). Target organ damage defined as left ventricular hypertrophy (LVH) on electrocardiogram (Sokolow-Lyon voltage > 3.8 mV and/or Cornell product > 2440 mm ms) or decline of estimated glomerular filtration rate (eGFR; < 60 mL/min per 1.73 m2) and other cardiovascular risk factors were investigated. Results: The results are summarized in the table. Blood pressure control was generally improved during the 9 years though the mean age of subjects was increased. The prevalence of impaired kidney function but not LVH and the number of subjects with risk factors were increased during the period. Sub-analysis in 537 subjects who visited in both 2010 and 2019 were performed and similar results were obtained (data not shown). Conclusions: Although blood pressure control was improved, total management of hypertensive subjects was not appropriate. Management of risk factors other than hypertension as well as blood pressure control is necessary in hypertensive subjects for extension of healthy life expectancy.