PS-P01-4: PREDICTORS FOR REVERSIBILITY OF MILD COGNITIVE IMPAIRMENT OVER 9 YEARS IN GENERAL POPULATION (TANUSHIMARU COHORT STUDY)

Abstract

Backgrounds: Prevention of dementia by preventing mild cognitive impairment (MCI) is very important, because the treatment for dementia has not been established. It is known that some of MCI convert to normal cognitive function, although its pathophysiology has not been elucidated. Currently, evidences of predictors for the cognitive reversibility are scarce, however, promoting cognitive improvement is necessary to prevent dementia. Therefore, we investigated the predictors of reversible MCI in a general population. Methods: We conducted medical interview, physical and blood tests and Mini-Mental State Examination (MMSE, 30 points) to assess cognitive function as a longitudinal cohort study in Tanushimaru in Japan in 2009 and 2018. Our study subject was 376 participants with MCI, which was defined as 24–27 points of MMSE, in 2009. Reversible MCI, which means MMSE score improvement to more than 28 in 2018, was defined as an outcome. Univariate and multivariate logistic regression analyses were used to analyze the association between life style factors in 2009 and reversible MCI. Traditional cardiovascular risk factors including were used as covariates. Results: Of the 376 subjects, 211 (56.1%) had reversible MCI. In fully adjusted logistic regression analyses, reversible MCI was significantly associated with higher body mass index (p = 0.003), history of alcohol intake (p = 0.009), taking lipid-lowering medication (p = 0.008), and less domains of impaired cognition in MMSE in 2009 (p = 0.01). The odds ratios (95% confidence interval) were 1.14 (1.05–1.24), 2.2 (1.2–3.8), 2.6 (1.3–5.3), and 0.62 (0.43–0.90). Conclusion: This study suggests some features of reversible MCI. Especially, we found that a possibility of a protective effect of lipid-lowering drugs on cognitive function. Further studies are needed to clarify the association.