PS-P01-2: ARTERIAL STIFFNESS IN PATIENTS WITH ARTERIAL HYPERTENSION INFLUENCED BY AGTR2 GENE G1675A POLYMORPHISM IN UZBEK POPULATION

Abstract

Material and Methods: 109 Uzbek male and female with I / III AH (ESH / ESC, 2018), mean age 54.1 ± 11.3 years, average duration of AH was 9.1 ± 5.9 years. Applanation tonometry was performed using SphygmoCor device (AtCor Medical, Australia) to measure the carotidfemoral pulse wave velocity (PWV). The genotyping of G1675A polymorphism of AGTR2 gene in 109 patients was carried out. Results are presented as M ± SD. For all types of analysis, P values less 0.05 were considered statistically significant. Results: 109 patients were examined and divided into two groups: 1st group with increased arterial stiffness: patients with pulse wave velocity (PWV) more 10 m/s (cases, n = 62) and 2nd group: patients with PWV less 10 m/s (controls, n = 47). 1st group, following distribution of G1675A polymorphism of AGTR2 gene was revealed: GG genotype determined in 54.8% of patients, GA genotype in 12.9%, AA genotype 32.3%, x2 = 18.21, P = 2.0. The allelic distribution showed the predominance of G allele carriers: G allele 61.3%, A allele 38.7%, x2 = 11.758, P = 0.000. 2nd group, the allelic distribution was uniform: A allele in 56.4% and G allele in 43.6%, respectively, x2 = 2.574, P = 0.109. The ratio of GG:GA:AA genotypes was as follows: 27.7%: 31.9%: 40.4%, x2 = 2.88, P = 0.09. An association of G allele with the development of arterial stiffness in patients with AH was found: among 62 patients of 1st group, G allele was common than in patients of 2nd group (61.3%; x2 = 6.72; p = 0.01; OR = 2.05, 95% CI 1.19–3.53) and only 38.7% of patients had A allele. That demonstrated an accumulation of GG genotype among patients of 1st group (54.8%; x2 = 9.66; P = 0.008; OR = 3.18, 95% CI 1.41), while GA genotype occurred in 12.9% of cases and AA genotype in 32.3% of cases. Whereas in the 2nd group, the GG genotype was less common in 27.7% of cases than the GA genotype (31.9%) and AA genotype (40.4%) cases. Conclusion: The study indicates greater accumulation of the G allele of the AGTR2 gene G1675A polymorphism among patients, where G allele and GG genotype are associated with the development of arterial stiffness in patients with AH of the Uzbek population.