PS-C22-7: RENAL FUNCTION AND URINARY PROTEIN 1 YEAR AFTER INITIATION OF ESAXERENONE

Abstract

Objective: It has been two years since the prescription of esaxerenone was started in Japan, but there are currently limited reports on clinical data after administration. The purpose of this study is to examine the real-world clinical data on renal function, urinary protein, and other clinical data on the esaxerenone-treated group compared to the non-administration group. Design and method: In this study, research subjects were selected from the patient population attending the Department of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine, Japan between March 1, 2021 and January 31, 2022. 354 patients treated with esaxerenone and 14,480 patients not treated with esaxerenone were compared on clinical indices 1 year after the initiation of treatment. Covariate adjustment by propensity score-matched analysis was carried out. Results: In the analysis of all patients, serum creatinine tended to increase after treatment with esaxerenone compared to before, but the difference was not significant. No consistent trend was observed for urinary protein and serum potassium. Conclusions: We are currently performing propensity score-matched analysis stratifying for blood pressure and urinary albumin to creatinine ratio at the start of treatment. COI: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work in this report.