PS-C18-9: THE ASSOCIATION BETWEEN FRAILTY OR SARCOPENIA AND INTRADIALYTIC HYPOTENSION

Abstract

Objective: Recently, osteoporosis, sarcopenia, and frailty have become prognostic issues due to the increasing number and aging population of dialysis patients. Dialysis patients have high bone and muscle fragility due to their unique pathology, and we previously investigated the association between osteoporosis and muscle mass or strength in the cross-sectional study. We found that shorter calf circumference and weaker grip strength were associated with lower bone mineral density and the risk for osteoporosis among hemodialysis patients, independently of the management of chronic kidney disease-mineral and bone disorder, nutritional status, and dialysis adequacy. On the other hand, intradialytic hypotension is also one of the most common intradialytic complications, which can affect dialysis adequacy and prognosis. Although sarcopenia and frailty have been reported to cause orthostatic hypotension, the association between sarcopenia or frailty and intradialytic hypotension is not clear. Therefore, in this study, we examined the association between sarcopenia or frailty and intradialytic hypotension using our previous osteoporosis study. Design and method: This was a single-center cross-sectional study. We screened patients aged 20 years or older who underwent hemodialysis three times a week and selected 200 patients with a history of hemodialysis for at least 6 months for the study. Calf circumference, grip strength, and normal walking speed were measured to assess sarcopenia, and frailty was diagnosed based on the Japanese version of the Cardiovascular Health Study criteria. The behavioral characteristics and clinical history were obtained using a questionnaire and medical records. We analyzed the association between the frequency of intradialytic hypotension and frailty, or physical functions related to sarcopenia. Results: The final analysis included 121 subjects, mean age 66.1 ± 12.6 years, 28 women (23.1%). Mean calf circumference was 35.6 cm ± 3.8 cm, grip strength was 27.8 kg ± 9.6 kg, 26 (21.5%) were frail, 64 (52.9%) were prefrail, and 31 (25.6%) were robust. We are currently collecting and analyzing the data and will present our findings at the conference. Conclusions: We plan to present the relationship between intradialytic hypotension and frailty or physical function at the conference.