PS-C15-3: CORRELATIONS BETWEEN CORONARY ARTERY DISEASE, CORONARY ARTERY CALCIUM SCORE, AND LIPOPROTEIN(A) LEVEL IN KOREA

Abstract

Background: Lipoprotein(a) levels are associated with coronary artery disease (CAD) and aortic valve calcification. This study aimed to determine the correlation between Lp(a) levels and coronary artery calcium (CAC) scores in patients who underwent coronary computed tomography angiography (CCTA). Methods: This was a single-center observational study. The patients had not been previously diagnosed with CAD and underwent CCTA and Lp(a) measurement within a three-month interval. Coronary angiography and further management were performed according to the physicians decision. Among 252 patients, 81 and 171 patients underwent coronary revascularization and received medical treatment, respectively. To examine the relationship between Lp(a) and CAC score and between Lp(a) and CAD, we divided the patients by Lp(a) level (50 mg/dL) and CAC score (400). Results: No relationship was observed between Lp(a) and CAD and other risk factors for that. There were no differences in the ratio of patients who underwent coronary revascularization and the CAC score according to an Lp(a) level of 50 ml/dL. There was no difference in Lp(a) level at a CAC level of 400. The proportion of patients who underwent coronary intervention was high in the high CAC score group (50.6% vs. 23.7%, p = 0.000). No association was observed between Lp(a) and CAC in the Pearson correlation (0.000, p < 0.998). Conclusion: Correlations between Lp(a) and CAC and between Lp(a) and CAD were not observed in Korean patients. However, a high CAC score was correlated with coronary revascularization.