PS-C14-4: PROLONGED QT AND ITS RELATION TO LEFT HEART SYSTOLIC FUNCTION IN HYPERTENSIVE PATIENTS

Abstract

Background: The aim of this study is to assess the prevalence of prolonged QTc in people with hypertension and its relation to left heart systolic function (evaluating by EF) in this group of patients. Method: The study was cross-sectional in design. Subjects were recruited from patients hospitalized in Cardiology Department, Hue University of Medicine and Pharmacy Hospital from May/2020 to Feb/2021, patients were diagnosed with hypertension according to ISH 2020 criteria and indicated to perform echocardiogram in order to evaluate their left heart systolic function (manifest as EF) and other related indices. Prolonged QTc was defined as QTc > 450 ms in females and > 460 ms in males. A p-value of < 0.05 was considered statistically significant. Results: Among 187 patients who agreed to participate in the research, 133 patients were qualified with all inclusion and exclusion criteria. 41 of them (30.8%) had prolonged QTc, while the remaining 92 (69.2%) had normal QTc interval. Patients with prolonged QTc had significantly higher prevalence of lower ejection fraction (EF), higher LVMI, besides, they also had higher prevalence of being diagnosed with heart failure, peripheral edema, dyspnea, higher mean heart rate (HR), longer PR interval compared to patients with normal QTc. Conclusion: This study demonstrated high prevalence of prolonged QTc in patients with hypertension. In the mentioned group, prolonged QTc has relation to left heart systolic function. In addition, affected patients also had significantly higher prevalence of factors associated with bad prognosis. Keywords: QTc, QT interval, hypertension, LVMI, EF, systolic dysfunction, Hue University of Medicine and Pharmacy Hospital.