PS-C02-9: ASSOCIATIONS OF SHORT-TERM BLOOD PRESSURE VARIABILITY WITH ELECTROCARDIOGRAM PARAMETERS IN OBESITY-RELATED HYPERTENSION

Abstract

Background: Both blood pressure variability (BPV) and mean blood pressure levels can induce target organ damage and affect the prognosis in patients with hypertension. The fluctuation of BPV is more obvious among patients with obesity-related hypertension, yet few researches have shown the correlation between BPV and electrocardiographic parameters. Objective: This study aimed to analyze the association of short-term BPV with electrocardiographic parameters, so as to identify the risk of arrhythmia in patients with obesity-related hypertension. Methods: All enrolled 330 subjects from the Department of Cardiovascular Medicine of the First Affiliated Hospital of Xi’an Jiaotong University were diagnosed with obesity-related hypertension. The short-term BPV, including standard deviation(SD), coefficient of variation(CoV), and weighted standard deviation(wSD), were analyzed by ambulatory blood pressure monitoring(ABPM). The atrial parameters(PR interval, maximum duration of P wave(Pmax), and P wave dispersion(Pwd)) and ventricular parameters(QT interval, Tpe interval, and Tpe/QT ratio) were measured on standard 12-lead electrocardiogram. Multivariate ordinary and binary logistic regression were conducted to evaluate the independent association between short-term BPV and electrocardiographic parameters. The study also analyzed the association of renin-angiotensin-aldosterone system (RAAS) with short-term BPV in 129 patients with obesity-related hypertension. Results: Although short-term BPV of 24 hours showed little association with electrocardiographic parameters, the association of daytime and nighttime BPV with electrocardiographic parameters was remarkably significant. And reverse dippers also showed longer Pmax than nondippers (P = 0.041). In this study, we found that the incidence of prolonged PR interval increased to 6% in patients with obesity-related hypertension, yet the prevalence was only 1% in healthy population younger than 60 years old. And those with a larger SD of nighttime systolic blood pressure had a longer PR interval(P = 0.025). Furthermore, ordinary logistic regression analysis showed that the nighttime CoV of diastolic blood pressure was independently correlated with PR interval. Meanwhile, logistic regression analysis also showed that the nocturnal blood pressure decline rate was independently associated with Tpe/QT ratio. However, the association of RAAS and short-term BPV was not significant. Conclusions: