PS-C02-11: ASSOCIATION BETWEEN BROAD P WAVE AND ECHOCARDIOGRAPHIC FINDINGS ON 12-LEAD ECG IN HYPERTENSIVE PATIENTS

Abstract

Background: Broad P waves have been shown to be associated with the development of atrial fibrillation and cardiovascular events. The relationship between broad P waves, left atrial and left ventricular findings assessed by echocardiography is unclear in hypertensive patients. Methods: We enrolled 3952 hypertensive patients in the Coupling study. P waves were measured by 12-lead electrocardiogram and defined broad P as P waves with a maximum P wave width ≧ 140 ms. Left atrial diameter (N = 436) and left ventricular mass index (LVMI, N = 736) were measured by echocardiography. LVH was defined as any LV mass 115 g/m2 in men and 95 g/m2 in women. Results: The Broad P group (N = 296) had more men and more history of heart failure than the control group (N = 3656) (men: 71 vs. 49%, p < 0.001; heart failure: 11 vs. 3%, p < 0.001). Office blood pressure levels did not differ significantly in both groups (systolic blood pressure: 136.3 ± 16.6 vs. 134.9 ± 16.2 mmHg, p = 0.15, diastolic blood pressure76.7 ± 10.7 vs. 77.0 ± 10.6 mmHg, p = 0.65). Left atrial diameter (LAD) and LVMI were greater in the broad P group than those in control group (LAD: 39.1 ± 6.3 vs. 35.3 ± 5.4 mm, p < 0.001, LVMI 116 ± 34 vs. 97 ± 22 g/m2, p < 0.001). After adjusting for age and sex, broad P was an independent determinant of LVH (odds ratio 3.40, 95% CI 1.91–6.04, p < 0.001). Conclusions: Broad P waves in hypertensive patients were independently associated with left ventricular hypertrophy and left atrial diameter.