PS-BPP05-5: HIGH LEVELS OF FATTY LIVER INDEX PREDICT NEW-ONSET HYPERTENSION WITH DYSGLYCEMIA

Abstract

Objective: To investigate whether the fatty liver index (FLI) predicts the development of hypertension in individuals with and without dysglycemia in the general Japanese population. Design and method: A total of 3114 participants including 1036 men and 2078 women who received specific health checkups in 2013 were observed until 2018. We defined dysglycemic as impaired fasting glucose (IFG) and diabetes mellitus. The participants were divided into 6 groups based on FLI tertile by sex and whether they had dysglycemia. The data was analyzed using the Cox proportional hazard model to calculate adjusted hazard ratios (HR) for the incident of hypertension. The model was adjusted for age, low-density lipoprotein, high-density lipoprotein, smoking and alcohol drinking, and further adjusted for systolic blood pressure (SBP) at baseline. Results: During a five-year follow-up period, a total of 853 of the 3114 participants had new onset hypertension. Using the low FLI group with normoglycemia as a reference, the risk of developing hypertension was significantly elevated in the high FLI group with normoglycemia, after confounders except for SBP, in male and female [HR (95% CI) male: high, 1.52 (1.06–2.17); female: high, 1.86 (1.43–2.42)], and also, in the high FLI group with dysglycemia, the risk was significantly elevated [male: low, 1.11(0.71–1.74); moderate, 1.58(1.05–2.39); high, 2.05(1.43–2.92); female: low, 1.56(0.97–2.49); moderate, 1.06(0.65–1.71); high, 2.98(2.19–4.07)]. After adjusting for SBP, the significance disappeared in high FLI with normoglycemia among male. meanwhile it remained unchanged in high FLI with normoglycemia in female and in high FLI with dysglycemia in male and female, respectively. Conclusions: Our study showed that FLI was independently associated with the risk of new-onset hypertension with or without dysglycemia. It suggests high FLI population, even in normoglycemia, should be managed for prevention of hypertension. The risk of developing hypertension was more pronounced in the dysglycemic population with high FLI, which may help predict subjects at high risk of developing hypertension in the dysglycemic population.