PS-BPP04-3: ASSOCIATION BETWEEN URINARY NA/K RATIO AND CHANGES IN COGNITIVE FUNCTION AND ALBUMINURIA OVER 10 YEARS IN A GENERAL POPULATION

Abstract

Objective: Preservation of cognitive function is an important issue in extending healthy life expectancy in an aging society. To elucidate factors associated with changes in cognitive function over a 10-year period in a general population. Design and method: A total of 984 subjects (381 males, 603 females, mean age 62.4 years) underwent a physical examination, blood test, urinalysis and the mini-mental state examination as an evaluation of cognitive function in 2009 and 2018. After excluding subjects with diabetes at baseline, the remaining subjects were followed-up 10 years later. Complete data sets were available from 890 subjects (330 males, 560 females, mean age 62.4 years) for prospective analysis. Logistic regression was performed to determine factors associated with changes in cognitive function and albuminuria after 10 years. Results: The logistic regression analysis revealed that the age (OR 1.11; 95%C.I: 1.08–1.14, p < 0.0001), sex (male, OR 0.59; 95%C.I: 0.38–0.91,P < 0.05), HbA1c (OR 2.18; 95%C.I: 1.13–4.23, P < 0.05), hs-CRP (OR 1.22; 95%C.I: 1.03–1.46, P < 0.05), and albuminuria(OR 1.48; 95%C.I: 1.19–1.83, p < 0.001) were associated with cognitive decline over 10 years. The age (OR 1.11; 95% C.I: 1.08–1.14, p < 0.0001) and albuminuria (OR 1.26; 95%C.I: 1.01–1.59, p < 0.05) were independently correlated to cognitive decline in stepwise logistic regression analysis. Furthermore, the age (OR 1.01; 95%C.I: 1.05–1.12, p < 0.0001), uric acid (OR 1.36; 95%C.I: 1.15–1.62, p < 0.001), insulin (OR 1.48; 95%C.I: 1.01–2.04, p < 0.05) and urinary Na/K ratio (OR 1.14; 95%C.I: 1.05–1.25, p < 0.01) were independently related to the progression of albuminuria over 10 years in stepwise logistic regression analysis. Conclusions: Urinary albuminuria and age were independently associated with 10-year cognitive decline, and urinary Na/K ratio was independently associated with progression of urinary albuminuria. The urinary Na/K ratio may have important significance in cognitive decline.