PS-BPC12-1: AGE-RELATED DIFFERENCES IN LONGITUDINAL ASSOCIATIONS BETWEEN ALCOHOL INTAKE AND ARTERIAL STIFFNESS, PRESSURE WAVE REFLECTION, AND INFLAMMATION IN MALE EMPLOYEES

Abstract

Backgrounds: The effect of alcohol intake on arterial stiffness related to macro-vascular damage, pressure wave reflection related to both macro- and micro- vascular damages and inflammation have not been fully concluded. Aims: In the present longitudinal observational study, which conducted in annually repeated measurements data, mixed model analyses were applied to examine the difference of longitudinal associations of amount of alcohol intake (i.e., non, mild, moderate and heavy) with arterial stiffness, pressure wave reflection and inflammation. Methods: In 4016 middle-aged (43 ± 9 years) healthy Japanese men without cardiovascular disease (CVD) at the study baseline, alcohol intake, which obtained by questionnaire, risk factors for CVD, brachial-ankle pulse wave velocity (brachial-ankle PWV), radial augmentation index (rAI), and serum C-reactive protein levels (CRP) were measured annually during a 9-year study period. Results: In this repeated measurements data, mix model linear regression analyses demonstrated that alcohol intake had a significant longitudinal association with brachial-ankle PWV and rAI in dose-dependent manner {i.e., non, Mild (1–10 g/day), Moderate (10–30 g/day) and heavy (Over 30 g/day) ethanol intake} (Figure). When baPWV was included as a covariate, the association of alcohol intake with rAI was significant. On the other hand, the serum CRP levels were significantly lower in mild to moderate alcohol intake groups as compared to other groups (i.e., U-shaped) (Figure). Conclusion: The amount of alcohol intake may have longitudinal linear association with increased arterial stiffness and abnormal pressure wave reflection, but it may have a U-shaped relationship with inflammation reflected by serum CRP levels. Thus, the alcohol intake may longitudinally affect both macro- and micro- vascular damages in a linear dose-dependent manner without mediating inflammation.