PS-BPC11-8: ASSOCIATION OF CARDIOMETABOLIC INDEX AND SUBCLINICAL RENAL DAMAGE: A CROSS SECTIONAL STUDY

Abstract

Objective: Subclinical renal damage (SRD) has become a major health issue due to its dormant onset and poor prognosis. Recent studies have found that cardiometabolic index (CMI) is closely related to diabetes, hypertension, stroke and cardiovascular disease. However, the correlation between CMI and SRD among adults without diabetes still remain unclear. The present study is aimed to investigate the association between CMI and SRD among non-diabetic individuals in a Chinese cohort. Design and method: A total of 2222 participants (male n = 1208) from our previously established cohort of Adolescent Hypertension Study were included in the cross-sectional survey. CMI was calculated by triglyceride to high density lipoprotein cholesterol ratio multiply waist-to-height ratio. Renal function was assessed with estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (uACR). The participants were divided into three groups according to CMI scores. The logistic regression model was established to analyze the relationship between CMI and the risk of SRD. Results: CMI was positively correlated with SRD. Compared to participants in the lowest tertile of CMI, those in the highest tertile of CMI had higher risk of SRD(OR:1.918, 95%CI:1.391–2.643,P < 0.001). The association remained significantly after adjusting related factors such as sex, age, history of hypertension, smoking, alcohol use, heart ratio and fasting blood glucose(OR:1.458, 95%CI:1.023–2.079, P < 0.05). Conclusions: Our study showed that cardiometabolic index was significantly associated with the risk of SRD in Chinese adults without diabetes. CMI may be used as a simple marker for detection of subclinical renal damage in non-diabetic subjects.