PS-BPC06-7: ASSOCIATION BETWEEN ISOLATED DIASTOLIC HYPERTENSION AND MICROALBUMINURIA AMONG KOREAN ADULTS

Abstract

Objective: Microalbuminuria acts as a sensitive marker of early nephropathy development and increased cardiovascular risk. Studies have reported that isolated diastolic hypertension (IDH) has an age-dependent association with cardiovascular disease (CVD) risks. However, little is known regarding renal dysfunctions associated with IDH. Therefore, this cross-sectional study aimed to evaluate the age-stratified association between IDH and microalbuminuria. Design and method: A total of 13,818 adults, including 5,916 men and 7,897 women, from Korea National Health and Nutritional Examination Survey (KNHANES) between 2011–2014 were included. Participants were categorized as having IDH or no IDH according to the 2017 American College of Cardiology/American Heart Association (ACC/AHA) Guideline. Microalbuminuria was defined as a urinary albumin-to-creatinine ratio of 30 to 300 mg/g from single-spot morning urine sample in accordance with the International Diabetes Federation definition. The youngest age group was defined as 19–39 years. The association between IDH and microalbuminuria was evaluated using logistic regression analysis with adjustment for covariates. Results: The mean age of participants with IDH was 47 years, younger than those with no IDH. There was a two-fold higher proportion of women than men with no IDH, and a higher proportion of men with IDH. Prevalence of microalbuminuria was higher in IDH group compared to no IDH group. With no IDH as a reference, the odds ratio (OR) of IDH for microalbuminuria in total was 1.21 (95% CI: 1.14–1.68). IDH also had significant ORs for prevalence of microalbuminuria in both of the older age groups (OR: 1.57, 95% CI: 1.17 -2.13 at 40–59 years, OR: 1.17, 95% CI: 1.06–2.10 at age ≧ 60). However, opposite result was found in the youngest age group (OR: 1.35, 95% CI: 0.98–2.38). Conclusion: IDH was positively associated with prevalence of microalbuminuria among middle-aged Koreans, but not with young adults. This study suggests potential significance of IDH in the development of cardiovascular diseases.