Abstract
Background: The renoprotective effects of long-term exercise in chronic renal failure have been reported. However, the details of the mechanism remains unclear. This study investigated the renal protective effect of long-term exercise on renal oxidative stress in a rat model of chronic renal failure. Methods: Male Sprague-Dawley rats were divided into Sham, 5/6 nephrectomy + sedentary, and 5/6 nephrectomy + exercise training groups. 5/6 nephrectomy + exercise training group underwent treadmill running for 12weeks. Systolic blood pressure and urinary protein were measured every 2 weeks. Renal function, renal histology and oxidative stress-related factors were examined after completion of the exercise protocol. Results: 5/6 nephrectomized rats exhibited hypertension, proteinuria, renal dysfunction glomerulosclerosis, renal interstitial fibrosis, and exercise training ameliorated them. 5/6 nephrectomy increased urinary malondialdehyde, renal cortical NADPH oxidase and xanthine oxidase activities and exercise training inhibited the 5/6 nephrectomy-increased urinary malondialdehyde, renal cortical NADPH oxidase and xanthine oxidase activities. Plasma malondialdehyde was not affected by 5/6 nephrectomy or exercise. Conclusions: In rats with chronic kidney disease, long-term exercise prevented hypertension, renal dysfunction, glomerulosclerosis, and renal interstitial fibrosis. Mechanism for the antihypertensive and renal protective effects of long-term exercise in chronic kidney disease may involve the reduction of renal oxidative stress.
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