PS-278 Automated Versus Manual Fio2 Control At Different Saturation Targets In Preterm Infants: Abstract PS-278 Table 1

Abstract

Background Preterm infants spend only 50% of time within the target oxygen saturation (SpO 2 ) during manual FiO 2 control (M-FiO 2 ). Automated FiO 2 control (A-FiO 2 ) improves SpO 2 targeting but it is uncertain if this applies to different SpO 2 target ranges and during non-invasive support (NIVS) and mechanical ventilation (MV). Objective To compare the efficacy of A-FiO 2 vs M-FiO 2 in keeping two different SpO 2 targets during NIVS or MV. Design/methods Preterm infants on FiO 2 >0.21 receiving NIVS or MV were randomised to SpO 2 targets 89–93% or 91–95% and underwent M-FiO 2 and A-FiO 2 for 24 h each, in random sequence. Results 80 infants (GA:26 w, age:18 d) were included (NIVS = 48, MV = 32). Time within target increased and below target decreased during A-FiO 2 compared with M-FiO 2 , especially in the lower target range. There was a reduction in time and hypoxemia episodes with SpO 2 2 . Outcomes did not differ between NIVS or MV. Conclusions Automated FiO 2 control improved SpO 2 targeting across different SpO 2 ranges and reduced hypoxemia with less workload during both NIVS and MV.