PS 17-60 CORRELATION BETWEEN LEFT VENTRICULAR DIASTOLIC DYSFUNCTION AND COGNITIVE IMPAIRMENT IN PATIENTS WITH HYPERTENSIVE HEART DISEASE

Abstract

Objective: To elucidate the relationship between left ventricular diastolic dysfunction and cognitive impairment in patients with hypertensive heart disease. Design and method: The Montreal Cognitive Assesment (MOCA) and echocardiography with tissue Doppler analysis were performed in 30 patients with hypertensive heart disease and preserved LV ejection fraction (EF > 40%). For statistical analysis, t-test, normality test using Shapiro-Wilks or Kolmogorov Smirnov test, followed by descriptive statistics and analysis of correlation between MOCA with a degree of diastolic dysfunction using the Spearman Rank analysis were performed. Results: Among 30 patients, 19 (63.3%) were diagnosed as CI (MOCA score < 26) and 11 (36.6 %) were diagnosed as no CI (MOCA score > or = 26). The ratio of early diastolic mitral inflow velocity to early mitral annular myocardial velocity by tissue Doppler (E/e’ Septal, E/e’ Lateral and E/e’ average) are no significantly different between the two groups and there were no correlation detected between (E/e’ Septal, E/e’ Lateral and E/e’ average) and the MOCA score (r = −0.229, p 0.112; r = −0.050, p 0.396; r = −0.168, p 0.187). Conclusions: LV diastolic dysfunction measured by the ratio of early diastolic mitral inflow velocity to early mitral annular myocardial velocity by tissue Doppler (E/e’) was not associated with cognitive impairment (CI) measured by MOCA score in patients with hypertensive heart disease.