PS 17-44 THE ASSOCIATION OF FOUR-LIMB BLOOD PRESSURE DIFFERENCES WITH CARDIOVASCULAR RISK FACTORS AND TARGET ORGAN DAMAGES IN COMMUNITY-DWELLING ELDERLY CHINESE

Abstract

Objective: Four-limb systolic blood pressure differences (SBPDs), including inter-arm SBPD (IASBPD), inter-leg SBPD (ILSBPD) and ankle-brachial index (ABI), were significantly associated with mortality. We aim to investigate the associations of those parameters with cardiovascular (CV) risk factors and target organ damages (TODs). Design and method: 1528 community-dwelling elderly participants with age 72.5 ± 5.9 years were recruited in the northern Shanghai. The four-limb BP was simultaneously measured by VP1000 (Omron, Japan). Under the framework of comprehensive cardiovascular examinations, conventional CV risk factors were assessed in each participant, and hypertensive TODs, namely left ventricular mass index (LVMI), ratio of transmitral early diastolic peak flow and early diastolic movement (E/Ea), carotid intima-media thickness (CIMT), carotid-femoral pulse wave velocity (CF-PWV), estimated glomerular filtration rate (eGFR) and urinary albumin/creatinine ratio (UACR), were all evaluated. Results: ABI was significantly correlated with most cardiovascular risk factors, whereas IASBPD was significantly correlated with several CV risk factors, including male gender (r = 0.05, P = 0.03), BMI (r = 0.20, P < 0.01), triglyceride (r = 0.07, P = 0.01) and HDL (r = −0.12, P < 0.01). While ILSBPD was only significantly correlated with age (r = 0.09, P < 0.01) and HDL (r = -0.09, P < 0.01), as seen in Table 3. Multiple linear and logistic regression analyses indicated the similar findings. On the contrary, after adjustment for potential covariates, those three SBPDs were only independently and significantly associated with CF-PWV and eGFR (all P < 0.05), but not with other hypertensive TODs, as shown in Table 4 and Figure 1. Conclusions: It seems that three four-limb SBPDs bear various cardiovascular burden, while they are mainly and significantly associated with atherosclerosis and renal dysfunction.