PS 11-17 DETERMINATION OF PARAOXONASE ENZYME ACTIVITY, TOTAL OXIDATIVE /ANTIOXIDATIVE CAPACITY AND ITS’ RELATIONSHIP WITH ATHEROSCLEROSIS IN YOUNG PATIENTS WITH ISCHEMIC CEREBROVASCULAR DISEASE AND THEIR FIRST DEGREE RELATIVES

Abstract

Objective: We aimed to determine the role of paraoxonase (PON) enzyme activity in the mechanism and way of familial inheritance of atherosclerotic cerebrovascular diseases, and also search the total antioxidant capacity (TAC), total oxidant capacity (TOC) and oxidative stress index (OSI) representing total oxidative and antioxidative capacity in patients with early onset atherosclerotic event and their relatives. Design and Method: Thirty-five patients (29 males; 16 females) treated with the diagnosis of cerebral infarction caused by atherosclerosis were included in the study. Men < 45 and female < 55 years of age were included. Control group consisted of 35 (18 males; 17 females) first degree relatives of the patients > 12 years. Paraoxanase, TAC and TOC were measured in both groups. Number Cruncher Statistical System 2007 Statistical Software (Utah, USA) was used for statistical analysis. Results: The mean age of patients and the controls were 44.54 and 33.23, respectively. Mean PON value was lower (198.78 ± 39.25) in the patients, compared to controls (207.39 ± 47.67) the difference was not statistically significant. In the patient group mean TAC, mean TOC and the OSI were 0.89 ± 0.14, 15.14 ± 2.43, and 17.55 ± 4.22, respectively. In the control group, mean TAC, mean TOC and OSI were 1.01 ± 0.22; 24.54 ± 11.04; and 25.87 ± 10.55, respectively. All 3 values of the patients were significantly lower than the controls. Furthermore, statistically significant negative relations were found between TAC value and age, total cholesterol and low density lipoprotein- cholesterol levels. Conclusions: Decreased PON enzyme activity and TAC as seen in the patient group may be a predictor of early onset atherosclerosis, and high levels of TOC and OSI as seen in the relative group may be a risk factor for atherosclerosis development.