PS-108 Urinary Biomarkers May Help Predict Outcome In Neonatal Encephalopathy

Abstract

Background Following a perinatal hypoxic-is chaemic insult, term infants are at risk of multi-organ injury including AKI. Infants with NE experience up-regulation of urinary cytokines which may reflect severity of brain injury. Objective To investigate the association between novel urinary biomarkers and outcome in a group of term infants with NE compared to controls. Methods Levels of urinary biomarkers [Albumin, B2M, Cystatin-C, EGF, NGAL, Osteopontin, Uromodulin] were serially measured over day 1–11 in a group of term newborns with NE and controls. These values were compared to grade of encephalopathy defined by Sarnat score. Results Ten control and 82 cases had urine samples collected (Grade 0 NE = 7, Grade I NE = 22, Grade II NE = 42, Grade III NE = 11). Thirty-nine infants underwent TH, 4 infants died. Control infants had significantly lower B2M on day 1, NGAL on day 1–2 and significantly higher urinary EGF on day 2–3 and Uromodulin on day 3, compared with cases (p-values Conclusion Infants with NE have elevated urinary biomarkers compared to controls. Abnormal grade of encephalopathy is best predicted by day 2 urinary Cystatin-C and day 3 NGAL. Urinary biomarkers may have a role in long term outcome prediction following NE.