PS 09-15 ANTIHYPERTENSIVE DRUG USE AND GENDER DIFFERENCE IN REAL WORLD PRACTICE

Abstract

Objective: We investigate the gender differences of antihypertensive drug utilization from a large cohort data. Design and Method: The cohort from KNHIS was composed of approximately one million insurance subscribers from 2002 to 2013 and released to researchers on the official procedure of data provision. This study was conducted using patients of this cohort, over 30 years old with diagnosis of hypertension and prescription records of antihypertensive drug at least 30 days in 2010 and 2011. Results: In total, 89,218 patients with hypertension were enrolled (Women 47,821, 53.6%). Women were older and the prevalence of hypertension in age 40∼60s was higher in men. Diabetes, ischemic heart disease and Atrial fibrillation were more common in men, however heart failure and cerebrovascular disease was more common in women. Patients treated with more than 2 antihypertensive drugs were more common in men. Male patients were treated in the general hospital more frequently. Women were more often prescribed diuretics only. Men were more often prescribed angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blocker (ARB) and calcium channel blockers and beta blocker. The frequency of uncontrolled blood pressure during antihypertensive drug therapy were same in both men and women. Use of a fixed dose combination drug was more often in men, especially ARB and CCB combination. Conclusions: The analysis of this large cohort revealed ACEI and ARB were the most frequently prescribed for hypertension treatment in Korea. Women with hypertension and under antihypertensive treatment were older than men and had heart failure more frequently and more often treated with diuretics, and men more often with ACEIs, ARB and CCB.