PS 08-52 BLOOD PRESSURE RELATED TO GLOMERULOMEGALY AND TUBULOINTERSTITIAL FIBROSIS IN CHRONIC GLOMERULONEPHRITIS

Abstract

Objective: Several factors contribute to the development of hypertension in patients with chronic glomerulonephritis (GN). This study was conducted to find the relationships between baseline blood pressure (BP) and clinico-pathological findings in patients with chronic GN. Design and Method: Clinico-pathological findings were analyzed in a total of 233 patients with chronic GN from The Kyung-Hee Cohort of GN. The glomerular surface area (GSA) was determined using imaging analysis software. The serum and urine angiotensinogen (AGT) concentrations were measured using human ELISA kits. Results: Mean serum creatinine concentration was 1.19 (0.5∼6.0) mg/dL. Systolic BP was > = 130 mmHg in 124 patients (53%) and > = 140 mmHg in 77 (33%). Systolic BP was positively correlated with serum uric acid concentrations and renal tissue findings including mean GSA and the degree of tubulointerstitial fibrosis and deposits of complement C3 and IgM and negatively with follow-up glomerular filtration rate and the slope of change in 1/serum creatinine for 2 years, while it has no significant relationships with serum and urine AGT and 24 hour urinary sodium excretion. Patients with systolic BP > = 130 mmHg as compared with those < 130 mmHg are older age and showed severer degree of clinico-pathological findings; baseline and follow-up serum creatinine, the amount of proteinuria, mean GSA, tubulointerstitial fibrosis and deposits of IgM and C3. Conclusions: This study showed that systolic BP was related to renal progression and pathological findings, glomerulomegaly and tubulointerstitial fibrosis, in patients with chronic GN.