PS 08-85 ASSOCIATION OF ALDOSTERONE SYNTHASE (CYP11B2) GENE POLYMORPHISMS WITH OBESITY IN ESSENTIAL HYPERTENSIVE CHILDREN AND ADOLESCENTS FROM THE URALS

Abstract

Objective: Polymorphisms of the aldosterone synthase gene, CYP11B2, have been suggested to be involved in the pathogenesis of arterial hypertension and obesity in adults, however the data in children are quite limited. The aim of the study was to investigate the association of CYP11B2 gene polymorphisms and the level of body mass index (BMI) in hypertensive children. Design and Method: The CYP11B2 −344T > C was genotyped in 54 hypertensive children and adolescents (76% of boys) aged 7–18 years. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques were used to assess CYP11B2 polymorphisms. Patients of the main group were divided according to CYP11B2 −344T > C into subgroups: I subgroup – children with CC/TC-allele (n = 44; 81,5 %), II subgroup - children with TT-allele (n = 10; 18,5 %). Results: The BMI level frequencies in CC/TC-carrier and TT-carrier were respectively as 25,9 and 21,4 in essential hypertensive subjects. The BMI was significantly higher in CC/TC children than in TT children (p Conclusions: Our study confirmed the association of the C-allele CYP11B2 −344T > C polymorphism with arterial hypertension and with obesity in children and adolescents. Our results are in agreement with experimental evidences suggesting that the renin-angiotensin-aldosterone system plays a role in the regulation of visceral adipose tissue accumulation.