Abstract
Objective: Central hemodynamics may better represent the load imposed on the coronary and cerebral arteries and thereby bear a stronger relationship to cardiovascular outcomes. Design and Method: Patients who confirmed hypertension by day-time 24hr ABPM (≥ 135/85 mmHg) were enrolled. All patients were measured central BP and radial augmentation index (AIx). We evaluated the associations of age and height, gender with central hemodynamics in patients with never treated hypertension. Results: A total 203 patients were enrolled, of whom men numbered 101 (49.7%). The median height of all patients was 162 cm, and mean age was 53.2 years. In the Pearson correlation analysis, height and AIx 75 showed a stronger relationship than age and AIx 75 regardless of gender difference (t = 3.615, p = 0.005). In the multiple regression analysis, the gender difference and the height was highly associated with elevated radial AIx75 (adjusted R2 = 0.428, 95% CI for women 1.480 to 10.995, p = 0.011 and 95% CI for age -0.929 t0 -0.335, p = 0.009, respectively). Conclusions: Of patients with never treated hypertension, the smaller height and female gender are the important risk factor for elevated radial AIx 75.
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