PS 08-47 CAN CLEATININE CLERARANCE BE USED AS A PREDITABLE MARKER OF CORONARY ARTERY STENOSIS BY MDCT ?

Abstract

Objective: Renal insufficiency is independently associated with increased cardiovascular disease (CVD)-related and all-cause mortality rates and CVD is strongly associated with coronary artery calcification. Aim of this study was to elucidate the relationship between renal function (cleatinine clerarance; CrCl) and coronary artery calcium Score (CACS) by MDCT. Design and Method: Between March 2009 and August 2011, 3188 subjects (mean age: 55 ± 10 years, M:F = 2103:1085) who visited the Heath Promotion Center of the Catholic University Seoul St. Mary's Hospital for a routine health check-up were enrolled. We estimated CACS/Framingham risk score (FRS) according to the stages of chronic kidney disease in K/DOQI guidelines. Results: There was a weak inverse correlation between CACS/FRS and CrCl in healthy subjects (r = −0.120, p < 0.001; r = −0.312, p < 0.001, respectively). In multivariate analysis, CrCl as well as the other conventional cardiovascular risk factors was an independent marker predicting the probability of moderate plaque burden or moderate non-obstructive coronary artery disease by MDCT after adjusted age and gender (OR: 0.969, 95%CI: 0.963–0.976, p < 0.001). The cut-off value less than 56.2 mL/min of CrCl showed 88 % of a sensitivity and 97% of a specificity for predicting the moderate plaque burden or moderate non-obstructive coronary artery disease by MDCT. Conclusions: CrCl is closely related to CACS and predicts the coronary artery stenosis by MDCT. Furthermore, it can be a comprehensive indicator of cardiovascular risk factors, including parameters of the FRS, in healthy subjects.