PS 05-75 СENTRAL AORTIC PRESSURE AND ARTERIAL STIFFNESS ASSESSMENT USING 24-HOUR AMBULATORY MONITORING IN HYPERTENSIVE SUBJECTS WITH METABOLIC SYNDROME AND HYPOTHYROIDISM

Abstract

Objective: To evaluate the parameters of the central aortic pressure (CAP) and arterial stiffness (AS) during the day in patients with arterial hypertension (AH) with metabolic syndrome (MS) and hypothyroidism (HT). Design and Method: The study included 64 subjects divided into 3 groups: 23 (35.9%) subjects with AH, 25 (39.1%) subjects with AH in the MS (AH + MS), 16 (25%) subjects with AH associated with HT (AH + HT). Control group (CG) were 22 practically healthy subjects. All the subjects underwent examination ABPM with oscillometric sensor (BPLab Vasotens, Russia) with assessment CAP (systolic blood pressure, SBPao; diastolic blood pressure DBPao; pulse pressure PPao; Augmentation index Alxao; amplification of pulse pressure, PPA) and AS (pulse wave velocity, PWVao). Results: Analysis of CAP showed a statistically significant increase all parameters in the all major groups examinees. The highest rates SBPao and DBPao was observed in the group of AH + HT (124.13 ± 15.62), (84.06 ± 9.06) compared with the CG (112.0 ± 6.68), (77.14 ± 5.84) [p < 0.01; p < 0.01]. PPao statistically significantly increased only in group AH + HT (40.0 ± 10.08) compared with the CG (34.9 ± 4.73) [p < 0.05]. The value of Alxao was higher in group AH (28.8 ± 19.35) and AH + HT (24.75 ± 14.76) compared with the CG (11.72 ± 12.21) [p < 0.01; p < 0.01] and AH + MS (14.68 ± 13.55) [p < 0.01; p < 0.05]. PPA was significantly low in the groups AН (124.61 ± 9.56) and AH + HT (126.44 ± 6.87) compared with the group of AH + MS (132.32 ± 9.03) [p < 0.01; p < 0.05] and CG (134.14 ± 6. 87) [p < 0.01; p < 0.01]. PWVao was reliably increase in group AH + HT (10.46 ± 1.65) and AH + MS (10.32 ± 1.45) compared with the group of AH (8.86 ± 1.37) [p < 0.01; p < 0.01] and CG (of 8.82 ± 1.38) [p < 0.01; p < 0.01]. Significant positive correlation of PWVao with SBPao and DBPao was observed (r = 0.73; r = 0.76; p < 0.05). Conclusions: 24-hour monitoring of CAP and AS revealed a deterioration of the elastic properties of central arteries in comorbid patients with MS and HT. Measurement of the CAP and AS necessary for the risk stratification of cardiovascular events in patients with comorbidities, including a thyroid hypofunction.