PS 05-26 RISK FACTORS AND COMPLIANCE IN HYPERTENSION ASSOCIATED WITH CORONARY ARTERY DISEASE PATIENTS – WEST SIBERIA RESIDENTS

Abstract

Objective: To study the risk factors (RF) prevalence and compliance in hypertension (Ht) associated with coronary artery diseases (CAD) pts – West Siberia residents. Design and Method: 151 pts with Ht grade 1–3 and stable angina 54,8 ± 0,7 years old divided in 3 groups. The 1st group included 43 Ht pts with uncomplicated angina and intact coronary arteries, the 2nd group - 47 Ht pts with angina and percutaneous coronary intervention last 1–3 years, the 3rd group - 61 Ht pts with myocardial infarction (MI) or stroke last 1–3 years. Methods included echocardiography, coronarography, Nt-pro BNP levels determination. Results: Active smokers number in 1st group were less than in other groups. 3rd group pts consumed significantly more alcohol before event. About 50% pts had sedentary lifestyle, about 70% - family Ht history. 75–84% pts had overweight and abdominal obesity. Hyper- and dyslipidemia were found at most pts too. 3rd group pts have most left ventricular myocardium mass index, most frequency multifocal atherosclerosis markers and most NT-pro BNP values. All pts before monitoring administered basic antihypertensive, antiplatelet agents and statins. The overage number of drugs consisted 3,0 ± 0,2, 3,9 ± 0,2 and 3,3 ± 0,2 at 1st-3rd groups accordingly for one patient (р1–2 = 0,02). Multi-component therapy compliance was 22, 68 and 31% at 1st, 2nd and 3rd groups (р1–2 = 0,006, р2–3 = 0,006). Most compliance associated with beta-blockers (91, 95, 86%) and ACE-inhibitors (45, 77, 56%) medication, the least – with statins (40–60%). Compliance decrease associated with lack treatment necessity understanding, lack higher education, lack family and satisfactory health. Conclusions: In Ht associated with CAD pts –West Siberia residents smoking associated with complicated course of angina and more number of coronary arteries lesion; alcohol consumption - with next events. Other RF frequency at Ht with complicated and no complicated angina have not differences. Ht associated with previous events characterized more organ-damage lesion frequency.