PS 02-08 Elevated Arterial Stiffness is Associated with Early Bone Loss in Healthy Subjects

Abstract

Objective: Both arterial stiffness and osteoporosis are the major causes of cardiovascular morbidity and mortality as well as age-related public health issues. We investigated the relationship between brachial-ankle pulse wave velocity (baPWV) for arterial stiffness and bone mineral density (BMD) for osteoporosis in healthy subjects. Design and Method: Participants in this study included 1,727 subjects (mean age: 55 ± 10 years, M:F = 914:813) who underwent routine health check-up between March 2009 and August 2011. We estimated baPWV using an automated oscillometric analyzer and BMD using dual energy x-ray absorptiometry and analyzed the gender difference after categorizing the subjects into 3 groups (normal, osteopenia, and osteoporosis) according to the World Health Organization (WHO) diagnostic classification. Results: There was a significant inverse correlation and gender difference between total BMD measured in the femur and right baPWV in both male (r = −0.136, p = 0.001) and female (r = −0.234, p < 0.001), respectively. In subgroup analysis according to the WHO diagnostic classification, there was a significant gender difference of right baPWV in normal (M:F = 1437 ± 203: 1309 ± 182 cm/sec, p < 0.001) and osteopenia group (M:F = 1508 ± 296: 1428 ± 243 cm/sec, p = 0.002), respectively. However, there was no gender difference in the osteoporosis group (1550 ± 316: 1570 ± 327 cm/sec, p = 0.616). After adjusting for age and gender, right baPWV was independently associated with osteopenia (Mvs.F = odds ratio (OR):1.003, 95% confidence interval(CI) 1.002-1.004, p < 0.001 vs. OR:1.003, 95%CI 1.001-1.009, p = 0.029, respectively) and osteoporosis (Mvs.F = OR:1.002, 95%CI 1.001-1.003, p < 0.001 vs. OR:1.005, 95%CI 1.001-1.009, p = 0.010, respectively) in both male and female, respectively. Conclusions: Arterial stiffness is elevated even in the osteopenia. Therefore more specific therapeutic strategies are important for pathophysioloic understanding of vascular damage during early bone loss period.