Abstract
Objective: Based on the study of some indicators of cellular and humoral immunity, evaluate the features of immunoreactivity in patients with psoriasis with concomitant pruritus. Materials and methods. Patients were examined with vulgar PS (n = 97), which were divided into 2 groups: group 1 - PS with pruritus (n = 73, mean age 40.0 ± 1.5 years), group 2 (comparison group) - PS without pruritus (n = 24, mean age 41.5 ± 2.7 years). The cellular immunity indicators was carried out by flow cytofluorimetry. Phagocytic activity of peripheral blood neutrophils was studied microscopically by the absorption of latex particles. Concentrations of immunoglobulins, cytokines, circulating immune complexes in the blood serum were evaluated by the method of enzyme-linked immunosorbent assay. Statistica 6.0 was used for statistical analysis. Our studies allowed us to identify features of PS with concomitant pruritus: severe clinical course of the disease with damage to the musculoskeletal system, associated with selective deficiency of class M immunoglobulins and increased activity of phagocytic neutrophils.
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