Pruritus and Atopic Dermatitis: from Etiological Features to Management

Nikolay N Murashkin,Roman A Ivanov,Leonid A Opryatin,Roman V Epishev,Alexander I Materikin,Dmitriy V Fedorov,Eduard T Ambarchian,Daria S Kukoleva

doi:10.15690/vsp.v19i6.2151

Nikolay N Murashkin, Roman A Ivanov + Show 6 more

Open Access

https://doi.org/10.15690/vsp.v19i6.2151

Copy DOI

Abstract

Pruritus is one of the main clinical manifestations of atopic dermatitis, and it significantly reduces the quality of life of patients in childhood. Scientific images on its pathophysiological basis have now undergone significant changes. The histamine exceptional role in pruritus development was confounded, as well as data on immune system involvement in its maintenance was given. This article presents current data on differential approaches to pruritus management depending on its etiopathogenetic characteristics. The role of dermocosmetics in restoration of the skin barrier as the first stage prevention of pruritus in atopic dermatitis was considered. The results of clinical studies showing efficacy of topical agents (innovative component with anti-pruritic action — STIMU-TEX) application are presented.

Highlights

Одним из основных клинических проявлений атопического дерматита является зуд, значительно ухудшающий качество жизни пациентов в детском возрасте
Pruritus is one of the main clinical manifestations of atopic dermatitis, and it significantly reduces the quality of life of patients in childhood
This article presents current data on differential approaches to pruritus management depending on its etiopathogenetic characteristics

Summary

Обзор литературы

Для цитирования: Мурашкин Н.Н., Опрятин Л.А., Епишев Р.В., Материкин А.И., Амбарчян Э.Т., Иванов Р.А., Федоров Д.В., Куколева Д.С. Зуд — один из часто встречающихся симптомов АтД. Pruritus is one of the main clinical manifestations of atopic dermatitis, and it significantly reduces the quality of life of patients in childhood. The role of dermocosmetics in restoration of the skin barrier as the first stage prevention of pruritus in atopic dermatitis was considered. For citation: Murashkin Nikolay N., Opryatin Leonid A., Epishev Roman V., Materikin Alexander I., Ambarchian Eduard T., Ivanov Roman A., Fedorov Dmitriy V., Kukoleva Daria S. Что зуд при АтД опосредуется периферическими С-волокнами, нейрогенно модулируется опиоидами и имеет к тому же психогенный компонент [6]. Vicious loops of pruritus in patients with atopic dermatitis (adapted from [7])

Проникновение аллергенов и ирритантов

Неврологические и психиатрические болезни

Вторая линия

Ионофорез гистамина