PRS69 - Impact, In Real Life Conditions, Of The Use Of A Purifier Spray On Allergy Care In Dust Mite Allergic Subjects

Abstract

The study has been set-up in order to evaluate in real life conditions the perceived efficacy of a spray containing essential oils on allergy-related-symptoms, day-sleepiness and QoL of allergic subjects. Women-and-men with a known history of dust mite allergy were recruited in the study. They were asked to use in their house twice a day, the purifier spray for a period of 28days. The perceived efficacy was evaluated via self-validated questionnaires on allergy symptoms (discomfort generated by sneezing- itchy eyes-stuffy nose-nasal flow-tiredness-ear itching), on daytime-sleepiness (Epworth-Sleepiness-Scale) and on QoL (SF12). For the study outcomes, each subject was evaluated at inclusion, at day7 and day28. The satisfaction through the CSQ8-questionnaire was also evaluated at day28. 42 subjects, with an history of allergy of 21.4±11.2years, were included. They present a symptom-score at inclusion of 6.63±3.5 which was significantly reduced after 7 days of spray use with a value of 3.87±2.4 (p<0,0001). The improvement was confirmed at day28:1.85±1.6-(p<0,0001). The data were also evaluated according to symptom severity, i.e.low, moderate or severe. For the moderate or severe subpopulations, a significant improvement was observed on the symptoms score since 7days of spray use. Moreover, for the subjects showing severe symptoms, an improvement was also observed on daytime-sleepiness (p<0,05) with the Epworth score going from 9.18 ±7.1 to 4.75 ±3.9 after 28days, and on the SF12 mental dimension score (42.8 vs 48.2-p<0,04) For the studied population the overall satisfaction evaluated was above 75% after 28days. By using self-validated-questionnaires, the evaluation shows the interest of the use of the essential oils spray in allergy care for dust mite allergic subjects. The improvement on symptoms is observed whatever the severity of symptoms is, and it is noticeable that for subjects showing severe symptoms, the quality of life and the sleep is also improved.