PRS4 Evidence Synthesis of Association of HLA-B*1502 Allele and Carbamazepine -Induced Stevens Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review

Abstract

OBJECTIVES: To evaluate Health Related Quality of Life (HRQoL) among generalpopulation of Quetta city, Pakistan. METHODS: The study was designed as a ques-tionnaire-basedcrosssectionalanalysis.EuropeanQualityofLifescale(EQ-5D)wasusedforassessmentofHRQoL.Atotalof1500healthyparticipantsfromMarch2011to July 2011, aging 18 years and above were approached. Descriptive statistics wereused to describe demographic characteristics of the general population. Percent-ages and frequencies were used to categorize the categorical variables, whilemeans and standard deviations were calculated for the continuous variables. In-ferential statistics (Mann-Whitney and Kruskal Wallis tests) were used where ap-propriate. HRQoL was scored using values adapted from the UK general populationsurvey. All analyses were performed using SPSS 16.0. RESULTS: One thousand fivehundred questionnaires were distributed and 1255 were returned (with responserate of 83.67%). Six hundred and forty three (51.2%) were males. Majority (n 427,34.0%)werecategorizedinagegroupof28-37years.Threehundredandthirtythree(26.5%) had intermediate level of education. Two hundred and ninety one (23.2%)had monthly income of in between 10001-15000 Pakistan rupees with 828 (66.0%)having urban residency. HRQoL was measured as 0.64 0.21 and VAS score was68.71 11.71. Only age and marital status, among all demographic characteristicshad significant relation with HRQoL score (p 0.05). CONCLUSIONS: Results of thepresent study provide the general health status of healthy population of Quettacity, Pakistan, which could sever as baseline data for further investigations.